| First Author | Ganeshan L | Year | 2010 |
| Journal | Biol Reprod | Volume | 83 |
| Issue | 6 | Pages | 958-64 |
| PubMed ID | 20739669 | Mgi Jnum | J:168160 |
| Mgi Id | MGI:4887293 | Doi | 10.1095/biolreprod.109.083162 |
| Citation | Ganeshan L, et al. (2010) Transformation-related protein 53 expression in the early mouse embryo compromises preimplantation embryonic development by preventing the formation of a proliferating inner cell mass. Biol Reprod 83(6):958-64 |
| abstractText | The developmental viability of the preimplantation embryo requires the successful formation of a cluster of pluripotent stem cells called the inner cell mass. Development is variably compromised by a range of exogenous stressors (including their production by assisted reproductive technologies). Inbred C57BL/6 strain embryos are particularly susceptible to the stresses associated with embryo culture, whereas hybrid embryos are more resistant, and this is accounted for in part by the overexpression of transformation-related protein 53 in cultured inbred embryos compared with similarly treated hybrid embryos or embryos not subjected to culture. We show here that this loss of viability is a consequence of the Trp53-dependent reduction in the capacity of blastocysts to form a proliferating inner cell mass. Formation of the trophectodermal line was not adversely affected by these stresses. |
