| First Author | Klein ME | Year | 2007 |
| Journal | Nat Neurosci | Volume | 10 |
| Issue | 12 | Pages | 1513-4 |
| PubMed ID | 17994015 | Mgi Jnum | J:130774 |
| Mgi Id | MGI:3772312 | Doi | 10.1038/nn2010 |
| Citation | Klein ME, et al. (2007) Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci 10(12):1513-4 |
| abstractText | Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression. |
