| First Author | Lubec B | Year | 1994 |
| Journal | Nephron | Volume | 67 |
| Issue | 2 | Pages | 214-7 |
| PubMed ID | 8072612 | Mgi Jnum | J:21179 |
| Mgi Id | MGI:69209 | Doi | 10.1159/000187931 |
| Citation | Lubec B, et al. (1994) Creatine reduces collagen accumulation in the kidneys of diabetic db/db mice. Nephron 67(2):214-7 |
| abstractText | In the present study, we tested the hypothesis whether creatine, a metabolite of arginine metabolism, shares the pharmacological activities of arginine reducing collagen accumulation in the diabetic kidney. Ten db/db mice were given, for 3 months, a solution containing a daily dosage of creatine of 50 mg/kg body weight. Eleven db/db mice served as controls. At the end of the 3-month study period, the mean N-carboxymethyllysine concentration in the untreated group was significantly higher than in the treated group (0.163 +/- 0.18 versus 0.096 +/- 0.017 nmol/mumol hydroxyproline, p < 0.001). Collagen accumulation was also significantly higher in the untreated than in the treated group (2.21 +/- 0.24 versus 1.68 +/- 0.22 mumol hydroxyproline/100 mg kidney weight, p < 0.001). We conclude that creatine led to a significant reduction in collagen type IV accumulation resembling arginine or aminoguanidine action. We do suggest that the guanidino group common to both compounds is able to block reactive carbonyls. |
