| First Author | Ang SL | Year | 1994 |
| Journal | Cell | Volume | 78 |
| Issue | 4 | Pages | 561-74 |
| PubMed ID | 8069909 | Mgi Jnum | J:19895 |
| Mgi Id | MGI:68015 | Doi | 10.1016/0092-8674(94)90522-3 |
| Citation | Ang SL, et al. (1994) HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78(4):561-74 |
| abstractText | HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3 beta is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos. |
