| First Author | Swanwick CC | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 8 | Pages | 1226-30 |
| PubMed ID | 19298817 | Mgi Jnum | J:147992 |
| Mgi Id | MGI:3843128 | Doi | 10.1016/j.febslet.2009.03.017 |
| Citation | Swanwick CC, et al. (2009) NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. FEBS Lett 583(8):1226-30 |
| abstractText | N-methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the brain. Here we demonstrate interactions between the NR2A and NR2B subunits of NMDARs with flotillin-1 (flot-1), a lipid raft-associated protein. When mapped, analogous regions in the far distal C-termini of NR2A and NR2B mediate binding to flot-1, and the prohibitin homology domain of flot-1 contains binding sites for NR2A and NR2B. Although NR2B can also directly bind to flot-2 via a separate region of its distal C-terminus, NMDARs were significantly more colocalized with flot-1 than flot-2 in cultured hippocampal neurons. Overall, this study defines a novel interaction between NMDARs and flotillins. |
