| Primary Identifier | IPR038002 | Type | Family |
| Short Name | BRD8 |
| description | Bromodomain-containing protein 8 (BRD8 or SMAP) is a component of the NuA4 histone acetyltransferase complex []and the SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome []. BRD8 contains two bromo domains. In Schizosaccharomyces pombe this component is known as bromodomain-containing protein 1 (bdc1).The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 []. |
