| Primary Identifier | IPR041818 | Type | Family |
| Short Name | Rab39 |
| description | This entry includes Ras-related proteins Rab39a and Rab39b. Rab39a is involved in phagosome maturation, inflammatory activation and neuritogenesis [, , ]. It also interacts with PI3K and negatively regulates the LPS-induced autophagy in macrophages []. Rab39b has also been found to be involved in autophagy and neuritogenesis []. Rab39a is widely expressed, while Rab39b is enriched in the brain []. Rabs are regulated by GTPase activating proteins (GAPs), which interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins [, ]. |
