| First Author | Hosick PA | Year | 2017 |
| Journal | Int J Mol Sci | Volume | 18 |
| Issue | 3 | PubMed ID | 28287466 |
| Mgi Jnum | J:268775 | Mgi Id | MGI:6273282 |
| Doi | 10.3390/ijms18030611 | Citation | Hosick PA, et al. (2017) Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice. Int J Mol Sci 18(3):611 |
| abstractText | Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice fed a normal-fat diet. Although body weights were not different in females fed a high fat diet, loss of HO-1 in adipocytes resulted in significant alterations in body composition. Adipose-specific HO-1 knockout resulted in increased fasting hyperglycemia and insulinemia in female but not male mice on both diets. Adipose-specific knockout of HO-1 resulted in a significant loss of HO activity and a decrease in the protein levels of adiponectin in adipose tissue. These results demonstrate that loss of HO-1 in adipocytes has greater effects on body fat and fasting hyperglycemia in a sex-dependent fashion and that expression of HO-1 in adipose tissue may have a greater protective role in females as compared to males. |
