| First Author | Rovere-Querini P | Year | 2004 |
| Journal | EMBO Rep | Volume | 5 |
| Issue | 8 | Pages | 825-30 |
| PubMed ID | 15272298 | Mgi Jnum | J:95096 |
| Mgi Id | MGI:3525022 | Doi | 10.1038/sj.embor.7400205 |
| Citation | Rovere-Querini P, et al. (2004) HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 5(8):825-30 |
| abstractText | Immune responses against pathogens require that microbial components promote the activation of antigen-presenting cells (APCs). Autoimmune diseases and graft rejections occur in the absence of pathogens; in these conditions, endogenous molecules, the so-called 'innate adjuvants', activate APCs. Necrotic cells contain and release innate adjuvants; necrotic cells also release high-mobility group B1 protein (HMGB1), an abundant and conserved constituent of vertebrate nuclei. Here, we show that necrotic HMGB1(-/-) cells have a reduced ability to activate APCs, and HMGB1 blockade reduces the activation induced by necrotic wild-type cell supernatants. In vivo, HMGB1 enhances the primary antibody responses to soluble antigens and transforms poorly immunogenic apoptotic lymphoma cells into efficient vaccines. |
