| First Author | Karam SD | Year | 2001 |
| Journal | J Comp Neurol | Volume | 440 |
| Issue | 2 | Pages | 127-35 |
| PubMed ID | 11745612 | Mgi Jnum | J:72510 |
| Mgi Id | MGI:2153180 | Doi | 10.1002/cne.1374 |
| Citation | Karam SD, et al. (2001) Granule cells migrate within raphes in the developing cerebellum: an evolutionarily conserved morphogenic event. J Comp Neurol 440(2):127-35 |
| abstractText | The early phase of granule cell migration in the developing chick cerebellum occurs within ribbons of cells moving through parasagittally arrayed gaps between Purkinje cell clusters. These parasagittal arrays of migrating granule cells, termed 'granule cell raphes,' also have been reported in rabbit and cat, but recent publications variously report that granule cell raphes are absent or present in rodents. By using Nissl counterstaining and Pax6 immunohistochemistry, we confirm that granule cells do migrate in raphes in the developing mouse cerebellum, and also in the primate cerebellum during a period of development that coincides with Purkinje cell compartmentation. In mouse and primate cerebellum, as in chick cerebellum, granule cell migratory streams occur at the borders of Purkinje cell clusters. GFAP immunostaining of Bergmann glial fibers shows no parasagittally localized pattern of distribution, indicating that the formation of granule cell ribbons is not prepatterned by heterogeneous distribution of radial glia. The conservation of the ribboned pattern of granule cell migration from bird to primate and the timing of this event suggest a possible role for granule cell raphes in parasagittal compartmentation of Purkinje cells. A potential mechanism for such an interaction is discussed. |
