| First Author | Pasare C | Year | 2004 |
| Journal | Immunity | Volume | 21 |
| Issue | 5 | Pages | 733-41 |
| PubMed ID | 15539158 | Mgi Jnum | J:93824 |
| Mgi Id | MGI:3505812 | Doi | 10.1016/j.immuni.2004.10.006 |
| Citation | Pasare C, et al. (2004) Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21(5):733-41 |
| abstractText | Toll-like receptors (TLRs) detect microbial infection and play an essential role in the induction of innate and adaptive immune responses. The mechanisms of TLR-mediated control of adaptive immunity are not yet fully understood. Induction of dendritic cell (DC) maturation is essential for activation of naive T cells. Here, we demonstrate that TLR-induced DC maturation and migration to the lymph nodes, in the absence of TLR-induced inflammatory cytokines, are not sufficient for T cell activation in vivo. We show that transient depletion of regulatory T (Tr) cells recovers the primary CD4 T cells response in MyD88-deficient mice, demonstrating that a major mechanism of TLR-mediated activation of T cell responses is the blocking of suppression by regulatory T cells. In addition we show that a TLR-induced signal(s) is required for memory CD4 T cell differentiation, but not for activation of memory T cells. |
