| First Author | Ryan JC | Year | 1992 |
| Journal | J Immunol | Volume | 149 |
| Issue | 5 | Pages | 1631-5 |
| PubMed ID | 1506685 | Mgi Jnum | J:2388 |
| Mgi Id | MGI:50911 | Doi | 10.4049/jimmunol.149.5.1631 |
| Citation | Ryan JC, et al. (1992) Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol 149(5):1631-5 |
| abstractText | In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands. |
