| Primary Identifier | IPR030720 | Type | Family |
| Short Name | Protocadherin-12 |
| description | Protocadherin-12 (Pcdh12), also known as vascular cadherin-2 or VE-cadherin-2, is located at the intercellular junctions of endothelial cells, where it promotes homotypic cellular adhesion []. It is required for placental development [, ]and its deficiency leads to modifications in the structure and function of arteries in adult mice [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns []. |
