Primary Identifier | MGI:3762757 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Shank1 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to replace exons 14 and 15, encoding almost the entire PDZ domain, with a PGK-neomycin drug resistance cassette. The absence of protein product was confirmed by western blot analysis on forebrain membrane extracts. |