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Publication : Different large deletions of T cell receptor V beta genes in natural populations of mice.

First Author  Jouvin-Marche E Year  1989
Journal  Eur J Immunol Volume  19
Issue  10 Pages  1921-6
PubMed ID  2573531 Mgi Jnum  J:21258
Mgi Id  MGI:69281 Doi  10.1002/eji.1830191024
Citation  Jouvin-Marche E, et al. (1989) Different large deletions of T cell receptor V beta genes in natural populations of mice. Eur J Immunol 19(10):1921-6
abstractText  A panel of geographically separate Mus m. domesticus and Swiss mice from several sources was screened for deletions in the T cell receptor variable (V) beta locus. Four out of forty-three strains tested show a deletion identical to or larger than the deletion previously described in SJL mice. To our knowledge, this is the first time that such important V beta deletions are described in inbred or partially inbred wild-derived strains of mice. On the other hand there seems to be very little polymorphism between the remaining V beta genes. Expression of V beta genes in peripheral and intra-thymic T cells was tested using antibodies specific for different V beta polypeptide chains. Flow cytometry analysis revealed a high expression of V beta 6 and V beta 17 genes in the Copacabana Swiss-derived strain and an absence of V beta 17 expression in the WLA wild-derived strain. The three Mus m. domesticus strains (WLA, DDO and WBG) having deleted two to three additional V beta subfamilies compared to SJL present no apparent immune deficiencies or autoimmune disorders. We conclude that relatively few V beta genes may suffice for unimpaired survival of wild mice and that there is a selective pressure for the structural conservation of the remaining V beta genes.
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