| First Author | Pullen AM | Year | 1988 |
| Journal | Nature | Volume | 335 |
| Issue | 6193 | Pages | 796-801 |
| PubMed ID | 3263572 | Mgi Jnum | J:30940 |
| Mgi Id | MGI:78222 | Doi | 10.1038/335796a0 |
| Citation | Pullen AM, et al. (1988) The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335(6193):796-801 |
| abstractText | T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease. |
