| First Author | Cho WG | Year | 2008 |
| Journal | Brain Res | Volume | 1219 |
| Pages | 59-65 | PubMed ID | 18538749 |
| Mgi Jnum | J:138406 | Mgi Id | MGI:3805128 |
| Doi | 10.1016/j.brainres.2008.04.043 | Citation | Cho WG, et al. (2008) Vanilloid receptor TRPV1-positive sensory afferents in the mouse ankle and knee joints. Brain Res 1219:59-65 |
| abstractText | TRPV1, a cation channel on sensory nerves sensitive to heat and capsaicin, plays an important role in the transduction of noxious stimuli to the spinal cord. It is expressed by neurons in dorsal root ganglia (DRG) that may also express neuropeptides, which are important for the development of inflammation. Mice with genetic deletion of TRPV1 have been used to study the involvement of this receptor in the mediation of pain and inflammation in animal models of arthritis. However, the expression of TRPV1 in the mouse articular afferents has not been studied. We here provide numerical data on expression of TRPV1 in an identified population of sensory afferents to the mouse L3-L5 DRG that innervate joints, in comparison with that from bladder and skin. A combination of tracing and immunohistochemistry revealed that TRPV1-positive fibers innervate the mouse knee and ankle. At the level of DRG, approximately 40% of articular afferents from these joints express TRPV1 and the majority of them are peptidergic, as revealed by simultaneous immunostaining for the neuropeptide calcitonin gene-related peptide. These findings are consistent with the idea that activation of TRPV1 in peripheral axons of joint afferents may mediate the synovial release of neuropeptides in arthritis. |
