| First Author | Scherer PE | Year | 1995 |
| Journal | J Biol Chem | Volume | 270 |
| Issue | 45 | Pages | 26746-9 |
| PubMed ID | 7592907 | Mgi Jnum | J:32963 |
| Mgi Id | MGI:80451 | Doi | 10.1074/jbc.270.45.26746 |
| Citation | Scherer PE, et al. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270(45):26746-9 |
| abstractText | We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes. |
