| First Author | Schuh W | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 7 | Pages | 3343-7 |
| PubMed ID | 14500626 | Mgi Jnum | J:85632 |
| Mgi Id | MGI:2675883 | Doi | 10.4049/jimmunol.171.7.3343 |
| Citation | Schuh W, et al. (2003) Cutting edge: signaling and cell surface expression of a micro H chain in the absence of lambda5: a paradigm revisited. J Immunol 171(7):3343-7 |
| abstractText | Pre-B cell receptor (pre-BCR) signals are essential for pro-B cells to mature efficiently into pre-B cells. The pre-BCR is an Ig-like transmembrane complex that is assembled from two micro H chains ( micro HC) and two surrogate L chains consisting of the non-covalently associated polypeptides VpreB and lambda5. In lambda5(-/-) mice, pro-B cell maturation is impaired, but not completely blocked, implying that a micro HC induces differentiation signals in the absence of lambda5. Using a mouse model, in which transgenic micro HC expression can be controlled by tetracycline, we show that in the absence of lambda5, the transgenic micro HC promotes in vivo differentiation of pro-B cells, induces IL-7-dependent cell growth, and is expressed on the surface of pre-B cells. Our findings not only show that an incomplete pre-BCR can initiate signals, but also challenge the paradigm that an IgHC must associate with an IgLC or a SLC to gain transport and signaling competency. |
