| First Author | Itäranta P | Year | 2002 |
| Journal | Genesis | Volume | 32 |
| Issue | 4 | Pages | 259-68 |
| PubMed ID | 11948913 | Mgi Jnum | J:76225 |
| Mgi Id | MGI:2178881 | Doi | 10.1002/gene.10079 |
| Citation | Itaranta P, et al. (2002) Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis 32(4):259-68 |
| abstractText | Summary: The embryonic kidney is a classic developmental model system for studying inductive tissue interactions that govern organogenesis. We report here that Wnt-6 is expressed in the ureter bud, and that cell lines expressing Wnt-6 induce nephrogenesis in vitro. Wnt-6 cells induce tubules with similar kinetics to spinal cord (SPC) and lead to induced expression of Pax2, Pax8, Sfrp2, and E-cadherin genes, early markers of tubulogenesis. Moreover, Wnt-6 signaling rescues tubulogenesis in mesenchyme separated from Wnt-4 mutant embryos and leads to activation of Wnt-4 transcription. Wnt-6 also induces a secondary axis in early Xenopus embryos. We conclude that Wnt-6 is a candidate for the ureter epithelium-derived signal that leads to activation of kidney tubulogenesis via Wnt-4. genesis 32:259-268, 2002. |
