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Protein Coding Gene : Akt2 thymoma viral proto-oncogene 2

Primary Identifier  MGI:104874 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  11652
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables protein serine/threonine kinase activity. Involved in positive regulation of protein targeting to membrane. Acts upstream of or within several processes, including cellular response to high light intensity; insulin receptor signaling pathway; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2).
PHENOTYPE: Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes. [provided by MGI curators]
  • synonyms:
  • PKB,
  • MGI:1923730,
  • thymoma viral proto-oncogene 2,
  • AW554154,
  • MGI:2142261,
  • MGD-MRK-28173,
  • RIKEN cDNA 2410016A19 gene,
  • expressed sequence AW554154,
  • 2410016A19Rik,
  • PKBbeta,
  • Akt2

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

75 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For