First Author | Yao Z | Year | 1997 |
Journal | Cytokine | Volume | 9 |
Issue | 11 | Pages | 794-800 |
PubMed ID | 9367539 | Mgi Jnum | J:44502 |
Mgi Id | MGI:1100386 | Doi | 10.1006/cyto.1997.0240 |
Citation | Yao Z, et al. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9(11):794-800 |
abstractText | Human interleukin 17 (hIL-17) is a T-cell derived cytokine that exhibits 63% amino acid sequence identity to mouse IL-17 (mIL-17) and 57% identity to a viral protein encoded by the herpesvirus saimiri (HSV) gene 13 (HVS13). The IL-17 family of proteins binds to a unique mouse receptor (mIL-17R). Using nucleic acid hybridization techniques, a cDNA encoding a human homologue of the mIL-17R (hIL-17R) was isolated from a human T cell library. The predicted amino acid sequence of the hIL-17R is 69% identical to the mIL-17R, shares no homology with previously identified cytokine receptor families, and exhibits a broad tissue distribution. The hIL-17R gene was localized to chromosome 22. Monoclonal antibodies (mAbs) generated against the hIL-17R were able to block the IL-17-induced production of cytokine from human foreskin fibroblast (HFF) cells. Binding studies suggest that recombinant hIL-17 binds to the hIL-17R with low affinity. Copyright 1997 Academic Press Limited. |