| First Author | Sempowski GD | Year | 1999 |
| Journal | Crit Rev Immunol | Volume | 19 |
| Issue | 4 | Pages | 331-48 |
| PubMed ID | 10530432 | Mgi Jnum | J:59705 |
| Mgi Id | MGI:1352075 | Citation | Sempowski GD, et al. (1999) Structure and function of the CD7 molecule. Crit Rev Immunol 19(4):331-48 |
| abstractText | CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Because of lack of identification of a natural ligand and lack of a monoclonal antibody against murine CD7, the in vivo functions of CD7 have until recently remained obscure. Recent studies in CD7-deficient mice have provided new insights into CD7 function, and demonstrated key roles for CD7 in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes. This article reviews recent work on the expression, structure, and function of CD7, and discusses roles the CD7 molecule might play in T and NK cell development and function. |
