| First Author | Washburn CP | Year | 2007 |
| Journal | Neurosci Bull | Volume | 23 |
| Issue | 5 | Pages | 249-55 |
| PubMed ID | 17952132 | Mgi Jnum | J:129898 |
| Mgi Id | MGI:3770362 | Doi | 10.1007/s12264-007-0037-7 |
| Citation | Washburn CP, et al. (2007) Expression of the tyrosine kinase receptor EphA5 and its ligand ephrin-A5 during mouse spinal cord development. Neurosci Bull 23(5):249-55 |
| abstractText | OBJECTIVES: To study the expression patterns of two Eph family molecules, the receptor EphA5, and the ligand ephrin-A5, during spinal cord development. METHODS: The receptor expression was analyzed using beta-galactosidase knockin mice, and affinity ligand probe binding. The ligand expression was assessed using two different affinity probes, and knockout mouse tissues as controls. RESULTS: EphA5 was expressed in the ventral spinal cord, while ephrin-A5 was located in the dorsolateral regions of the spinal cord throughout development. CONCLUSIONS: These results show that EphA5 and ephrin-A5 are expressed over broad developmental stages and may play important roles in establishing the dorsoventral organization of the spinal cord. |
