| First Author | Tan L | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 12 | Pages | 3657-3671.e4 |
| PubMed ID | 31216482 | Mgi Jnum | J:287191 |
| Mgi Id | MGI:6390684 | Doi | 10.1016/j.celrep.2019.05.064 |
| Citation | Tan L, et al. (2019) Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vgamma6(+) T Cells to Skin Residency as Activated Effector Cells. Cell Rep 27(12):3657-3671.e4 |
| abstractText | IL-17-producing gammadelta T cells express oligoclonal Vgamma4(+) and Vgamma6(+) TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understood. Here, single-cell RNA-seq profiling identifies IL-17-producing Vgamma6(+) T cells as a highly homogeneous Scart1(+) population in contrast to their Scart2(+) IL-17-producing Vgamma4(+) T cell counterparts. Parabiosis demonstrates that Vgamma6(+) T cells are fairly tissue resident in the thymus, peripheral lymph nodes, and skin. There, Scart1(+) Vgamma6(+) T cells display tissue-specific gene expression signatures in the skin, characterized by steady-state production of the cytokines IL-17A and amphiregulin as well as by high expression of the anti-apoptotic Bcl2a1 protein family. Together, this study demonstrates how Scart1(+) Vgamma6(+) T cells undergo tissue-specific functional adaptation to persist as effector cells in their skin habitat. |
