| Primary Identifier | MGI:1339963 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 20454 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable lactosylceramide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; brain; liver; spleen; and testis. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). PHENOTYPE: Targeted inactivation of this gene leads to inability to synthesize GM3 ganglioside. Homozygotes for a null allele exhibit enhanced sensitivity to insulin. Homozygotes for a different null allele show resistance to botulinum neurotoxin type C. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
