| First Author | Lin GH | Year | 2012 |
| Journal | Eur J Immunol | Volume | 42 |
| Issue | 11 | Pages | 2861-74 |
| PubMed ID | 22886791 | Mgi Jnum | J:188780 |
| Mgi Id | MGI:5442225 | Doi | 10.1002/eji.201242503 |
| Citation | Lin GH, et al. (2012) Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8+ memory T cells in the bone marrow. Eur J Immunol 42(11):2861-74 |
| abstractText | The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4-1BBL supports the antigen-independent survival of CD8+ memory T cells. Here, we show that mice lacking 4-1BB only on alphabeta T cells show a similar defect in CD8+ T-cell recall responses, as previously shown in 4-1BBL-deficient mice. We show that 4-1BB is selectively expressed on BM CD8+ but not CD4+ memory T cells of unimmunized mice. Its ligand, 4-1BBL, is found on VCAM-1+ stromal cells, CD11c+ cells, and a Gr1(lo) myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory T cells into mice lacking 4-1BBL only on radioresistant cells recapitulates the defect in CD8+ T-cell survival seen in the complete knockout mice, with smaller effects of 4-1BBL on hematopoietic cells. In BM, adoptively transferred DsRed CD8+ memory T cells are most often found in proximity to VCAM-1+ cells or Gr1+ cells, followed by B220+ cells and to a much lesser extent near CD11c+ cells. Thus, a VCAM-1+CD45(-) stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BBL to CD8+ memory T cells in the BM. |
