| First Author | Nguyen HM | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 45 | Pages | 18577-82 |
| PubMed ID | 23090990 | Mgi Jnum | J:191240 |
| Mgi Id | MGI:5461285 | Doi | 10.1073/pnas.1209142109 |
| Citation | Nguyen HM, et al. (2012) Modulation of voltage-gated K+ channels by the sodium channel beta1 subunit. Proc Natl Acad Sci U S A 109(45):18577-82 |
| abstractText | Voltage-gated sodium (Na(V)) and potassium (K(V)) channels are critical components of neuronal action potential generation and propagation. Here, we report that Na(V)beta1 encoded by SCN1b, an integral subunit of Na(V) channels, coassembles with and modulates the biophysical properties of K(V)1 and K(V)7 channels, but not K(V)3 channels, in an isoform-specific manner. Distinct domains of Na(V)beta1 are involved in modulation of the different K(V) channels. Studies with channel chimeras demonstrate that Na(V)beta1-mediated changes in activation kinetics and voltage dependence of activation require interaction of Na(V)beta1 with the channel's voltage-sensing domain, whereas changes in inactivation and deactivation require interaction with the channel's pore domain. A molecular model based on docking studies shows Na(V)beta1 lying in the crevice between the voltage-sensing and pore domains of K(V) channels, making significant contacts with the S1 and S5 segments. Cross-modulation of Na(V) and K(V) channels by Na(V)beta1 may promote diversity and flexibility in the overall control of cellular excitability and signaling. |
