| First Author | Lee JE | Year | 2015 |
| Journal | PLoS One | Volume | 10 |
| Issue | 9 | Pages | e0137776 |
| PubMed ID | 26367121 | Mgi Jnum | J:243100 |
| Mgi Id | MGI:5907592 | Doi | 10.1371/journal.pone.0137776 |
| Citation | Lee JE, et al. (2015) Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses. PLoS One 10(9):e0137776 |
| abstractText | Differentiation of T cells is closely associated with dynamic changes in nutrient and energy metabolism. However, the extent to which specific metabolic pathways and molecular components are determinative of CD8+ T cell fate remains unclear. It has been previously established in various tissues that acetyl CoA carboxylase 2 (ACC2) regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria. Here, we explore the cell-intrinsic role of ACC2 in T cell immunity in response to infections. We report here that ACC2 deficiency results in a marginal increase of cellular FAO in CD8+ T cells, but does not appear to influence antigen-specific effector and memory CD8+ T cell responses during infection with listeria or lymphocytic choriomeningitis virus. These results suggest that ACC2 is dispensable for CD8+ T cell responses. |
