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Publication : Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.

First Author  Coussens L Year  1986
Journal  Science Volume  233
Issue  4766 Pages  859-66
PubMed ID  3755548 Mgi Jnum  J:8380
Mgi Id  MGI:56847 Doi  10.1126/science.3755548
Citation  Coussens L, et al. (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233(4766):859-66
abstractText  A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
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