First Author | Coussens L | Year | 1986 |
Journal | Science | Volume | 233 |
Issue | 4766 | Pages | 859-66 |
PubMed ID | 3755548 | Mgi Jnum | J:8380 |
Mgi Id | MGI:56847 | Doi | 10.1126/science.3755548 |
Citation | Coussens L, et al. (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233(4766):859-66 |
abstractText | A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses. |