| Primary Identifier | MGI:2181182 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 170762 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to be a structural constituent of nuclear pore. Acts upstream of or within with a positive effect on miRNA processing and protein localization to nucleus. Acts upstream of or within atrial cardiac muscle cell action potential; mRNA export from nucleus; and protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). PHENOTYPE: Homozygotes for a gene trap allele die prior to E8.5 while heterozygotes develop atrial fibrillation with shortened action potential duration. Homozygotes for a knock-out allele show complete embryonic lethality prior to organogenesis with failure of blastocysts to hatch from the zona pellucida and form in vitro outgrowths. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
