| Primary Identifier | MGI:2443630 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 243958 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable SH2 domain binding activity; phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of immunoglobulin production; negative regulation of inflammatory response to wounding; and regulation of B cell proliferation. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in liver and thymus primordium. Orthologous to several human genes including SIGLEC10 (sialic acid binding Ig like lectin 10). PHENOTYPE: Mice homozygous for a null allele exhibit increased B-1 cell numbers, increased IgM levels and IgM-producing plasma cells, and produce more IgM autoantibodies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
