Primary Identifier | IPR015641 | Type | Family |
Short Name | FEZ_2 |
description | The gene unc-76 (unc, uncoordinated) is necessary for normal axonal bundling and elongation within axon bundles in Caenorhabditis elegans. Two human homologues, fasciculation and elongation protein zeta-1 and -2 (FEZ1 and 2) have been identified [].FEZ2 has been reported in rat, human and mouse. Similar to FEZ1, FEZ2 interactes with PKCzeta and induces neurite extension of PC12 cells when co-expressed with a constitutively active mutant of PKCzeta []. |