|  Help  |  About  |  Contact Us

Allele : Otp<tm1Tlu> orthopedia homeobox; targeted mutation 1, Thomas Lufkin

Primary Identifier  MGI:2387865 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Otp
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Sequence encoding the third helix of the homeodomain was disrupted by the insertion of a lacZ reporter cassette. The inserted cassette contained stop codons in all three reading frames, precluding the translation of the endogenous carboxy terminal, which is involved in transactivation. Comparisons with wild-type in situ hybridization results showed that the expression of lacZ was similar to the endogenous expression pattern.
  • mutations:
  • Insertion
  • synonyms:
  • Otp<lacZ>,
  • Otp<lacZ>
Quick Links:
 
Quick Links:
 

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele