| Type | MGI:General | Description | brains of 4-month old mice have abnormal intraneuronal aggregates of Abeta peptide 1-42 immunoreactivity throughout, particularly in the Ammon's horn in the hippocampus compared to pale homogeneous staining in control brains presence of Abeta is observed as punctate deposits within neurons having a rounded, compact appearance intracellular accumulation of amyloid immunoreactivity is prominent within the hilar region of the hippocampus, with strong reactivity in the pyramidal cell layer of Ammon's horn with immunoreactivity extending beyond the cell body in punctate deposits in short, somewhat curly abnormal-appearing fibers in hippocampal pyramidal cells in transgenic mouse brains, immunoreactivity to F5 which is specific for for the 9 carboxy terminal APP amino acids extends beyond the some into the neuronal processes in contrast to controls where F5 is distributed uniformly throughout the neuronal somata; pyramidal cells stain densely in the neuropil in transgenic brains, and F5 reactivity is observed in larger accumulations in the soma compared to wild-type mice |
