Primary Identifier | MGI:5289965 | Allele Type | Transgenic |
Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(tetO-SNCA)7Vle |
Strain of Origin | Not Specified | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This transgene consists of the human wild-type alpha-synuclein cDNA under the control of the tetracycline responsive promoter. Alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression. |