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Type  developmental stage Description  First detected at low levels at 10.5 dpc in cranofacial mesenchyme and in parts of the nervous system. At 12.5 dpc, high expression found in heart, diaphragm, bronchi and in the mesenchyme surrounding precartilage condensations. At later stages, expressed in dental papilla, dermis, hair follicles and in the perichondrium and in regions containing chondro and osteo progenitor cells.