Primary Identifier | MGI:6392346 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Bdnf |
Transmission | Germline | Strain of Origin | C57BL/6NJcl |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 9 was replaced with a floxed neomycin resistance cassette and a modified exon 9 with the nucleotide substitution of GCT to ATG that results in the amino acid substitution of methionine for valine at position 68. This mutation mimics a human polymorphism associated with psychiatric disorders. Cre-mediated recombination removed the selection cassette. |