| First Author | Pérez-Caro M | Year | 2009 |
| Journal | EMBO J | Volume | 28 |
| Issue | 1 | Pages | 8-20 |
| PubMed ID | 19037256 | Mgi Jnum | J:144382 |
| Mgi Id | MGI:3830806 | Doi | 10.1038/emboj.2008.253 |
| Citation | Perez-Caro M, et al. (2009) Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J 28(1):8-20 |
| abstractText | In human cancers, all cancerous cells carry the oncogenic genetic lesions. However, to elucidate whether cancer is a stem cell-driven tissue, we have developed a strategy to limit oncogene expression to the stem cell compartment in a transgenic mouse setting. Here, we focus on the effects of the BCR-ABLp210 oncogene, associated with chronic myeloid leukaemia (CML) in humans. We show that CML phenotype and biology can be established in mice by restricting BCR-ABLp210 expression to stem cell antigen 1 (Sca1)(+) cells. The course of the disease in Sca1-BCR-ABLp210 mice was not modified on STI571 treatment. However, BCR-ABLp210-induced CML is reversible through the unique elimination of the cancer stem cells (CSCs). Overall, our data show that oncogene expression in Sca1(+) cells is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that elimination of the CSCs is enough to eradicate the whole tumour. |
