| Primary Identifier | IPR039184 | Type | Family |
| Short Name | SARM1 |
| description | SARM1 (sterile alpha and TIR motif-containing protein 1) is a TIR (Toll-interleukin 1 receptor) adaptor that downregulates Toll-like receptor signalling [, , ]. It plays a role in innate immunity []. It is also an essential mediator of axon degeneration know as Wallerian degeneration [, ]. A specific motif in its TIR domain is responsible for NAD+ loss and injury-induced SARM1 activation [, ]. |
