| First Author | Chandra A | Year | 2011 |
| Journal | Nat Cell Biol | Volume | 14 |
| Issue | 2 | Pages | 148-58 |
| PubMed ID | 22179043 | Mgi Jnum | J:178896 |
| Mgi Id | MGI:5300609 | Doi | 10.1038/ncb2394 |
| Citation | Chandra A, et al. (2011) The GDI-like solubilizing factor PDEdelta sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol 14(2):148-58 |
| abstractText | We identify a role for the GDI-like solubilizing factor (GSF) PDEdelta in modulating signalling through Ras family G proteins by sustaining their dynamic distribution in cellular membranes. We show that the GDI-like pocket of PDEdelta binds and solubilizes farnesylated Ras proteins, thereby enhancing their diffusion in the cytoplasm. This mechanism allows more effective trapping of depalmitoylated Ras proteins at the Golgi and polycationic Ras proteins at the plasma membrane to counter the entropic tendency to distribute these proteins over all intracellular membranes. Thus, PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane; conversely, PDEdelta down-modulation randomizes Ras distributions to all membranes in the cell and suppresses regulated signalling through wild-type Ras and also constitutive oncogenic Ras signalling in cancer cells. Our findings link the activity of PDEdelta in determining Ras protein topography to Ras-dependent signalling. |
