| Primary Identifier | IPR018998 | Type | Domain |
| Short Name | EndoU_C |
| description | This entry represents the EndoU domain found at the C-terminal of EndoU endoribonucleases, which carries out a conserved RNA processing function. The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends. The EndoU domain is an α/β domain, that contains nine α-helices and three antiparallel β-sheets; the latter are clustered on one side of the domain, whereas the α-helices are largely on the other side []. It contains a conserved trio of catalytic residues, two histidines and a lysine.EndoU is a family of metal-dependent endoribonucleases that is broadly conserved among eukaryotes [, ]. EndoU family members have RNA-binding and endoribonuclease activities and appear to be involved in many aspects ofbiology, including small nucleolar RNA biogenesis, endoplasmic reticulum (ER) network formation, immune response, and neurodegeneration:Xenopus laevis endoribonuclease XendoU is responsible for processing the intron encoded U16 and U86 small nucleolar RNAs (snoRNAs) [, , ].Human EndoU, also known as PP11 (placental protein 11), has an endoribonuclease activity with placental tissue specificity [, , ].Drosophila melanogaster CG2145 and DendoU endoribonucleases [].Caenorhabditis elegans endu-2 regulates nucleotide metabolism and germ cell proliferation in response to nucleotide imbalance and other genotoxic stress []. |
