| Primary Identifier | MGI:1916510 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 69260 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in flagellated sperm motility; male gamete generation; and seminiferous tubule development. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2). PHENOTYPE: Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
