Primary Identifier | MGI:109339 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 14050 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within DNA repair and chromatin organization. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; rhombomere; and sensory organ. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit abnormal heart function, decreased grip strength and increased exploratory behavior. [provided by MGI curators] |