| First Author | Yan J | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 246 |
| Issue | 1 | Pages | 222-7 |
| PubMed ID | 9600096 | Mgi Jnum | J:47612 |
| Mgi Id | MGI:1203840 | Doi | 10.1006/bbrc.1998.8546 |
| Citation | Yan J, et al. (1998) Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun 246(1):222-7 |
| abstractText | A novel protein kinase related to the C. Elegans serine/ threonine kinase UNC-51 was cloned from mouse. The UNC-51- Like Kinase (ULK)1 is encoded by a cDNA of 1051 amino acids with calculated MW of 113 kDa. Comparison of the ULK1 and UNC-51 shows the highest conservation in the amino-terminal kinase domain, which is followed by a proline/serine-rich (PS) domain and a conserved carboxyl- terminal (C) domain. ULK1 mRNA is expressed in various tissues, and is mapped to mouse chromosome 5F and rat chromosome 12q16.3, by fluorescent in situ hybridization. PIA-tagged ULK1 is expressed as a protein of similar to 150 kDa in COS7 cells and is auto-phosphorylated in vitro in its PS domain. We propose that ULK1, UNC-51 and a yeast protein kinase Apg1p comprise a novel subfamily of protein kinase, which is structurally conserved among eukaryotes. (C) 1998 Academic Press. |
