| First Author | Chai L | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 388 |
| Issue | 3 | Pages | 543-8 |
| PubMed ID | 19679103 | Mgi Jnum | J:153543 |
| Mgi Id | MGI:4365690 | Doi | 10.1016/j.bbrc.2009.08.043 |
| Citation | Chai L, et al. (2009) LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. Biochem Biophys Res Commun 388(3):543-8 |
| abstractText | We have identified a new functional transmembrane receptor, LRRC19 (leucine-rich repeat containing 19), that belongs to the LRR protein family. LRRC19's central core has four analogous LRR repeating modules in a juxtaposed array and a casein kinase (CK2) phosphorylation site in the cytoplasmic domain. LRRC19 mRNA was found in the kidney, spleen and intestine of adult mice using both RT-PCR and in situ hybridization. LRRC19 does not contain a cytoplasmic Toll/IL-1 receptor (TIR) domain but was able to activate NF-kappaB and induce production of proinflammatory cytokines. LRRC19 shares a close evolutionary relationship with multiple Toll-like receptors (TLRs), especially TLR3. Importantly, the TLR3 ligand, as well as other TLR ligands, significantly promoted the expression of proinflammatory cytokines and the activation of NF-kappaB by LRRC19. Thus, LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney. |
