| First Author | Wong K | Year | 2001 |
| Journal | Cell | Volume | 107 |
| Issue | 2 | Pages | 209-21 |
| PubMed ID | 11672528 | Mgi Jnum | J:72329 |
| Mgi Id | MGI:2152475 | Doi | 10.1016/s0092-8674(01)00530-x |
| Citation | Wong K, et al. (2001) Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell 107(2):209-21 |
| abstractText | The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs). Two of the Slit-Robo GAPs (srGAPs) are expressed in regions responsive to Slit. Slit increased srGAP1-Robo1 interaction and inactivated Cdc42. A dominant negative srGAP1 blocked Slit inactivation of Cdc42 and Slit repulsion of migratory cells from the anterior subventricular zone (SVZa) of the forebrain. A constitutively active Cdc42 blocked the repulsive effect of Slit. These results have demonstrated important roles for GAPs and Cdc42 in neuronal migration. We propose a signal transduction pathway from the extracellular guidance cue to intracellular actin polymerization. |
