| First Author | Clement RL | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 10 | Pages | 1360-1371 |
| PubMed ID | 31477921 | Mgi Jnum | J:305783 |
| Mgi Id | MGI:6706504 | Doi | 10.1038/s41590-019-0472-4 |
| Citation | Clement RL, et al. (2019) Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol 20(10):1360-1371 |
| abstractText | Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still unclear due to a lack of specific tools. A TFR cell-deleter mouse was developed that selectively deletes TFR cells, facilitating temporal studies. TFR cells were found to regulate early, but not late, germinal center (GC) responses to control antigen-specific antibody and B cell memory. Deletion of TFR cells also resulted in increased self-reactive immunoglobulin (Ig) G and IgE. The increased IgE levels led us to interrogate the role of TFR cells in house dust mite models. TFR cells were found to control TFH13 cell-induced IgE. In vivo, loss of TFR cells increased house-dust-mite-specific IgE and lung inflammation. Thus, TFR cells control IgG and IgE responses to vaccines, allergens and autoantigens, and exert critical immunoregulatory functions before GC formation. |
