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Protein Coding Gene : Ago4 argonaute RISC catalytic subunit 4

Primary Identifier  MGI:1924100 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  76850
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables RNA binding activity. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and miRNA metabolic process. Located in P-body and nucleus. Part of RISC complex. Is expressed in several structures, including central nervous system; lung; sensory organ; tooth; and vibrissa. Orthologous to human AGO4 (argonaute RISC component 4).
PHENOTYPE: Male mice homozygous for a null mutation display oligozoospermia, decreased testis weight, premature entry into meiosis and disruption of sex body formation. However both males and females are fertile. [provided by MGI curators]
  • synonyms:
  • Ago4,
  • 5730550L01Rik,
  • argonaute 4,
  • argonaute RISC catalytic subunit 4,
  • AI481660,
  • eukaryotic translation initiation factor 2C, 4,
  • expressed sequence AI481660,
  • RIKEN cDNA 5730550L01 gene,
  • Eif2c4,
  • MGI:2140312

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

5 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For