| Primary Identifier | MGI:98834 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 22059 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to radiation; intrinsic apoptotic signaling pathway; and positive regulation of programmed cell death. Acts upstream of or within several processes, including mitochondrion organization; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including chromosome; germ cell nucleus; and mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study several diseases, including breast cancer (multiple); lung cancer (multiple); non-Hodgkin lymphoma (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). PHENOTYPE: Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
